翻訳と辞書 Words near each other ・ Modified Arts ・ Modified Ashworth scale ・ Modified atmosphere ・ Modified atmosphere/modified humidity packaging ・ Modified car ・ Modified Checklist for Autism in Toddlers ・ Modified Chee's medium ・ Modified citrus pectin ・ Modified Compression Field Theory ・ Modified condition/decision coverage ・ Modified Dall–Kirkham telescope ・ Modified Dietz method ・ Modified discrete cosine transform ・ Modified due-date scheduling heuristic ・ Modified Frequency Modulation ・ Modified GRF (1-29) ・ Modified Harvard architecture ・ Modified Hotchkiss machine gun ・ Modified Huffman coding ・ Modified hyperbolic tangent ・ Modified internal rate of return ・ Modified KdV-Burgers equation ・ Modified lognormal power-law distribution ・ Modified Maddrey's discriminant function ・ Modified milk ingredients ・ Modified models of gravity ・ Modified Modular Jack ・ Modified Morlet wavelet ・ Modified Motors Magazine ・ Modified Newtonian dynamics Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Modified GRF (1-29) ： ウィキペディア英語版 Modified GRF (1-29) Modified GRF (1-29) often abbreviated as mod GRF (1-29), originally known as tetrasubstitued GRF (1-29), is a term used to identify a 29 amino acid peptide analogue of growth-hormone-releasing hormone (GHRH), a releasing hormone of growth hormone (GH). It is a modified version of the shortest fully functional fragment of GHRH, often referred to as growth hormone releasing factor (1-29) (abbreviated as GRF (1-29)), and also known by its standardized name, sermorelin. ==Origin== The first 29 amino acids of GHRH were discovered to be as equally potent as its full 44 amino acid structure This fragment became known as GRF (1-29). However, due to a rapid metabolic clearance analogues of GRF (1-29) were synthesized to enhance the biological activity and reduce the rapidity of metabolic clearance. These analogues were primarily created by substituting amino acids within the peptide structure for amino acids more resistant to enzymatic cleavage. One early analogue substituted the amino acid L-alanine (abbreviated as Ala or A) at the 2nd position of the peptide structure for its optical isomer (mirror image), D-alanine (abbreviated as D-Ala). This substitution resulted in a peptide bond between D-Ala and the 3rd amino acid in the structure aspartic acid (Asp) more able to resist rapid cleavage by the enzyme dipeptidyl peptidase-4, a cleavage which had previously led to an inactive peptide fragment. This successful modification prompted the further creation of analogues with additional amino acid substitutions. In 2005, the first specific mention of tetrasubstitued GRF (1-29) appeared in a study that used it as one of the GRF (1-29) analogue peptide structures studied. The term was used to describe the replacement of the 2nd, 8th, 15th, and 27th amino acids in the structure of GRF (1-29). In 2008, a researcher known as DatBtrue created the term modified GRF (1-29) in place of tetrasubstitued GRF (1-29) in his public articles. Continued use of the term on public and private forums has popularized and standardized the nomenclature. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Modified GRF (1-29)」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.